Best Levothyroxine Tablets Manufacturer

LEVOTHYROXINE TABLETS

It is used to treat an underactive thyroid (hypothyroidism). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland.

Dosage and Administration :

Usual Adult Dose for Hypothyroidism : Hypothyroidism in adults and in children in whom growth and puberty are complete, Therapy may begin at full replacement doses in otherwise healthy individuals less than 50 years old and in those older than 50 years who have been recently treated for hyperthyroidism or who have been hypothyroid for only a short time (such as a few months), Average full replacement dose : 1.7 mcg/kg/day (e.g., 100 to 125 mcg/day for a 70 kg adult) orally. Older patients may require less than 1 mcg/kg/day Doses greater than 200 mcg/day orally are seldom required An inadequate response to oral daily doses of 300 mcg/day or greater is rare and may indicate poor compliance, malabsorption, and/or drug interactions.

For most patients older than 50 years or for patients under 50 years of age with underlying cardiac disease : Initial dose : 25 to 50 mcg/day, with gradual increments in dose at 6 to 8 week intervals, as needed.

Patients with severe hypothyroidism : Initial dose : 12.5 to 50 mcg orally once a day; dosage can be increased in 12.5 to 25 mcg/day increments every 2 to 4 weeks (accompanied by clinical and laboratory assessment, until the TSH level is normalized).

Mode of action :

Levothyroxine acts like the endogenous thyroid hormone thyroxine (T₄, a tetra-iodinated tyrosine derivative). In the liver and kidney, T₄ is converted to T₃, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.

Strength and Packing :

Strength : 25/50/100/150/200 mcg
Packing : Tablets 10's