CONJUGATED ESTROGEN TABLETS
It is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.
Dosage and Administration :
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- Vulvar and Vaginal Atrophy due to Menopause - Patients should be treated with the lowest effective dose. Generally, women should be started at 0.3 mg PREMARIN daily. Subsequent dosage adjustment may be made based upon the individual patient response. Treatment of Hypoestrogenism due to Hypogonadism, Castration, or Primary Ovarian Failure - The therapy should be initiated and maintained with the lowest effective dose to achieve clinical goals. Female hypogonadism: 0.3 mg or 0.625 mg daily, administered cyclically (e.g., three weeks on and one week off). Doses are adjusted depending on the severity of symptoms and responsiveness of the endometrium.
Mode of action :
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- Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–pituitary gland. This action stimulates the growth of the ovarian follicle and thus initiates ovulation.
Strength and Packing :
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- Strength : 0.3 mg / 0.625 mg / 1.25 mg
Packing : Tablets 28's
- Strength : 0.3 mg / 0.625 mg / 1.25 mg